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Health & Wellness Articles  ›  Dealing with Depression

Antidepressants & Weight Gain

How to Get Help without Gaining Weight

-- By Dean Anderson, Behavioral Psychology Expert
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For many people, depression and weight problems go hand in hand. Depression itself is highly associated with changes in weight. In fact, significant weight loss or gain is one of the symptoms used to diagnose depression. And research has shown that up to 25% of the people who take antidepressant medications may also experience weight gain. Needless to say, finding yourself in that group can be very frustrating.

While we know there is a connection between depression, antidepressant medications and weight gain, it's impossible to predict how a particular medication will affect your weight, or what other side effects it might have for you. And even if you do start gaining weight after starting on antidepressants, it will be hard to know for certain if the medication is causing the problem, or if changing it will solve the problem.

This means that, if you do find yourself gaining weight when taking antidepressant meds, you and your doctor may need to do some real detective work to figure out what's going on and what to do about it. It can be hard enough finding a medication that works well on your depression with minimal side effects, so giving up an effective medication for the chance that a different one might cause less weight gain can be a dangerous proposition.

Here's some general information that can help you do this necessary detective work, so that you and your doctor can make the right decision for you.

Why do antidepressant medications lead to weight gain?
The answer is multifaceted. Sometimes the weight gain may simply be due to the fact that the medication is actually working. For many people, depression causes loss of normal appetite, reduced interest in food, or an inability to experience the pleasure you normally get from eating. If that was the case for you, it could be that you're simply eating more food now because the medication is helping you get back to "normal" eating habits. Or maybe you're feeling a little better than normal, and eating more for the pleasure of it, without even realizing that's what you're doing. Changing your medication probably won't make much difference here. In this case, you'll just need to work on balancing your eating and exercise to get your weight where you want it to be.

But medications can have other effects as well. In some people, they can increase appetite above and beyond what's "normal," or even increase cravings for certain foods, especially carbohydrates. Sometimes people gain weight even though their actual eating habits haven't changed, so it's also possible that antidepressant medications can alter your basic metabolism.
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About The Author

Dean Anderson Dean Anderson
Dean Anderson has master's degrees in human services (behavioral psychology/stress management) and liberal studies. His interest in healthy living began at the age of 50 when he confronted his own morbid obesity and health issues. He joined SparkPeople and lost 150 pounds and regained his health. Dean has earned a personal training certification from ACE and received training as a lifestyle and weight management consultant. See all of Dean's articles.

Member Comments

  • Excellent article! I'm a psych nurse, a type II diabetic, and have depression. This is a question often asked by patients new to antidepressant medication, and these are the answers I give, too. There is so much involved! I hope everyone reads this article, it's so important. - 4/21/2013 1:20:17 PM
  • I always wondered if the Zoloft was helping me to lose wieght. I've been taking it for about 2 months, and i actually was able to drop 10 pounds whereas before, i've been struggling to lose it. - 3/25/2013 8:53:00 PM
  • KANIPHA
    Came across this article. I took Zoloft for about 4 months (starting in October 2010) for anxiety and lost 20 lbs in the first three weeks doing NOTHING special and have not gained any of it back. Still need to lose quite a bit more :-) But from what I can find online, weight GAIN on Zoloft is unusual. Those who've posted that they gained weight on Zoloft were taking it for some sort of depression, though. Very different from anxiety. - 3/14/2013 11:47:40 PM
  • I am more curious about how anti-depressants might make eating moderately and counting calories harder. My doctor had offered to let me reduce the dose that I take but I am not sure if I should since my sense of hope has a very STRONG influence on whether I binge. (I have trouble having a reason to work hard at counting calories because of this hope thing.) - 3/12/2013 2:53:45 PM
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