The U.S. Food and Drug Administration (FDA) does not regulate dietary supplements, which means that supplements with little to no research on safety or effectiveness are sold in stores and online every day. "Natural" or not, supplements can lead to overmedication, drug interactions, and serious side effects. It probably isn't a good idea to forgo your conventional medical treatment and rely on supplements alone. It's extremely important to always tell your doctor if you are using a dietary supplement or if you are even thinking about combining a dietary supplement with your conventional medical treatment. Discuss the following supplements with your doctor to decide which ones might be right for you.
A derivative of the amino acid tryptophan, 5-HTP (5-hydroxy-L-tryptophan), is converted into the neurotransmitter serotonin in the brain. Supplementing 5-HTP is possibly effective in helping to increase the levels of serotonin in the brain, which helps regulate mood, sleep and appetite. However, additional research is needed. Side effects include: nausea, constipation, gas, drowsiness, and reduced libido. In high doses, 5-HTP may cause liver problems and aggravate asthma.
A number of studies indicate that fish oil supplements, which are high in omega-3s, may be effective at treating depression—when combined with medical treatment. All fish oil supplements are different, so it's important to read labels and discuss them with your doctor. Specifically, the fatty acid EPA (eicosapentaenoic acid), which is found in fatty fish and fish oil, is the most beneficial. According to research, taking 1-2 grams of EPA orally (along with standard antidepressant therapy), improves depression symptoms. In contrast, DHA (docosahexaenoic acid), which is also found in fatty fish and fish oil, does not appear to have these same effects.
Folic Acid is a B-vitamin. Taking folic acid (folate) supplements with conventional antidepressant medication might improve the treatment response for those with depression. However, current research suggests that folic acid is not an effective replacement for antidepressant medication therapy. Continued ›
Dietary Supplements for Depression
What Does the Research Really Show?
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