Antidepressants & Weight Gain

For many people, depression and weight problems go hand in hand. Depression itself is highly associated with changes in weight. In fact, significant weight loss or gain is one of the symptoms used to diagnose depression. And research has shown that up to 25% of the people who take antidepressant medications may also experience weight gain. Needless to say, finding yourself in that group can be very frustrating.

While we know there is a connection between depression, antidepressant medications and weight gain, it's impossible to predict how a particular medication will affect your weight, or what other side effects it might have for you. And even if you do start gaining weight after starting on antidepressants, it will be hard to know for certain if the medication is causing the problem, or if changing it will solve the problem.

This means that, if you do find yourself gaining weight when taking antidepressant meds, you and your doctor may need to do some real detective work to figure out what's going on and what to do about it. It can be hard enough finding a medication that works well on your depression with minimal side effects, so giving up an effective medication for the chance that a different one might cause less weight gain can be a dangerous proposition.

Here's some general information that can help you do this necessary detective work, so that you and your doctor can make the right decision for you.

Why do antidepressant medications lead to weight gain?
The answer is multifaceted. Sometimes the weight gain may simply be due to the fact that the medication is actually working. For many people, depression causes loss of normal appetite, reduced interest in food, or an inability to experience the pleasure you normally get from eating. If that was the case for you, it could be that you're simply eating more food now because the medication is helping you get back to "normal" eating habits. Or maybe you're feeling a little better than normal, and eating more for the pleasure of it, without even realizing that's what you're doing. Changing your medication probably won't make much difference here. In this case, you'll just need to work on balancing your eating and exercise to get your weight where you want it to be.

But medications can have other effects as well. In some people, they can increase appetite above and beyond what's "normal," or even increase cravings for certain foods, especially carbohydrates. Sometimes people gain weight even though their actual eating habits haven't changed, so it's also possible that antidepressant medications can alter your basic metabolism.
ACTION STEP: Start by carefully tracking your food intake and exercise for several weeks using an online tracker to find out exactly how much you're eating and where your calories are coming from. Also start a basic journal describing anything that feels out of the ordinary to you—whether your appetite is heartier than usual, you're exercising more or less than usual, or you're experiencing food cravings that are really hard to resist. If you find that you're having a lot of trouble managing your appetite or cravings, or that your weight is going up even though you're sure you're not eating more or exercising less than before, then it's time to talk to your doctor about the situation. Bring these records with you when you go.

Should I change medications to prevent weight gain?
The side effects of virtually all antidepressant medications can potentially include weight gain. But since individuals vary a great deal in whether or how much any particular medication will cause this or any other side effect, changing medications can be an effective way to deal with this problem. There's no way to predict in advance how you'll react to any specific medication, but studies have shown that some medications are more commonly associated with weight gain than others. Among the selective serotonin reuptake inhibitor (SSRI) drugs commonly prescribed, Paxil seems to be associated with weight gain most often, while Zoloft is at the other end of the spectrum. The SNRI (serotonin and norepinephrine reuptake inhibitor) drugs Effexor and Serzone don't seem to cause weight gain in most people, and Welbutrin may actually cause weight loss for some individuals. There is also evidence that combining two different antidepressant medications, or adding a small dosage of certain other medications (such as anti-seizure medications), can also reduce problems with weight gain. So, changing drugs can make a difference.

The downside of changing drugs, of course, is that this could also affect your depression symptoms. The brain chemistry of depression is extremely complex and varies from person to person, which is why some drugs work for you while others don't. It may take some experimentation to find something that will do the job on your depression without affecting your weight, and that can take some time.

ACTION STEP: Talk over your options thoroughly with your doctor, and don't stop taking a medication, change your dosage, or add any weight-loss supplements or OTC depression remedies without discussing it first with your doctor. Some combinations can be very dangerous, and others may cancel each other out.

Is there anything else I can do to prevent weight gain when taking antidepressants?
For some people, changing medications won't be an option because the drug they're using is the one they need to control depression symptoms; in these cases some weight gain may be unavoidable if you want to keep your depression symptoms under control. Or you may have to wait until your mood stabilizes enough to do some experimentation with other medications.

If your weight gain is very troubling, it can take a lot of courage and determination to do the right thing for your overall health and well-being (staying on antidepressants), and resist the temptation to do whatever is necessary to lose the weight. Getting the right kind of support can be crucial to getting through this situation, so be sure to talk it over with your doctor and family and friends—you might be surprised to learn that you're not alone in dealing with this problem.

ACTION STEP: As always when you're talking about weight management, a balanced, healthy diet and plenty of exercise are the foundations of success. Regular exercise not only burns calories to help keep your weight gain to a minimum, it can improve mood, reduce the effects of stress, and help you enjoy life more—even if you are carrying a few more pounds than you'd like. Likewise, a healthy diet can make it easier for your brain to keep your neurotransmitters in balance and avoid big swings in energy levels and mood that can provoke depressive reactions. Be careful to avoid extreme weight-loss diets, as this can have the opposite effect.  Many people find that the combination of a diet and exercise are enough, over time, to reduce or eliminate the weight gain associated with antidepressant medications.
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Member Comments

My depression was because of grief. My Dad died in 2018, and even though my Dad wasn't kind to me up to 2019 I was really missing him, without realizing it. I have worked through my grief. Even with this pandemic, just getting outside and enjoying the sunshine and occasionally going shopping, I have made a decision to be happy every day. I have days of sadness when I miss my parents, thus sometimes leading to emotional eating. It also helps that I have a faith in God. I know not every depression is the same. This Thursday, it will be 15 years since my Mom passed away. I agreed to meet my counselor in person that day because I don't know how that day may affect me. It is not a concern to me that I haven't been able to lose weight. I'm taking Sertraline (Zoloft) so I don't know what effect that has on my weight. Report
Taking care of myself with healthy eating and mild exercise is the only anti-depressant I need. Report
Thanks Report
I'm glad that the Depression I take medication for is not the same depression I get when I realize I'm not losing the weight or even gaining some back. However, suffering from chemical and emotional depression combined is not wonderful.

Thanks for the action steps, and the impetus we need to strive for better and communicate with our doctors. Report
Awesome...thanks for sharing! Report
thanks for the share Report
Thanks for th interesting article:) Report
To those posting that the antidepressants you have taken left you in a vegetative state unable to laugh or cry it doesnt sound like you were on the right one for you. If you truly suffer from depression you would know that unfortunately it is not possible to just quit medication, eat healthy, get exercise and live a happy existence. Depression is a mental illness that can kill. I would think that anybody in their right mind would rather be happy and have a few extra pounds then skinny and depressed. I personally have been skinny and depressed and joyful and plump and can attest that how I feel inside is a heck of a lot more important than how I look outside. Because of the antidepressants I take I am alive and able to get out of bed each day.....I am able to go on a run, a hike or a bike ride and eat a healthy diet which I hope at one point will lead to me being at a weight that I am comfortable with. Even if my weight never changes I am in a good head space and at the end of the day it is my mind set that determines the quality of my life way more than my pant size. I hope all of us here suffering from depression can find something that helps bring back some joy in our lives. Just know that sometimes it takes a little medication to help guide us down the right road to find the joy in life its nothing to be embarrassed about . Report
Interesting article. Report
I will just speak for myself .... Over ten years ago, my physician decided I "needed" anti-depressants! .... This was the worst carnival ride I ever went on! .... In that time, I was blatto ... I had O emotions ... just flat line. I never laughed and I never cried. My husband and those who knew me well did not know me when I was in this state. Many nights I had little to no sleep .... and would lay there waiting to repeat another awful day. .... At one point I got very thin; only later to turn to food and gain to my highest weight ever. I will absolutely NEVER ever consider a pill to alter my moods as these certainly did ....... Like I say, it was one nasty downer!
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I don’t have unipolar but I’ve been on some gainers’s been a matter usually of more hungry & most recently I was barely eating & it was just me getting my appetite back. I’ve since lost a lot of the weight. Thankfully my mood stabilizer is not a gainer, at least for me, but lamictal does seem to be pretty weight neutral. I notice my appetite is normal on it & I’m pretty up there dosage wise. I am on a low dose antidepressant (not an SSRI....those mess with me & informed my bipolar diagnosis back in ‘05) & seemingly no effect in that sense, I’m sleeping great though which is actually why I take it. Report
Add Diabetes into the mix, and life becomes even more complicated. It's not easy to be constantly vigilant, but vigilant we must be. Good luck to us all. 8-) Report
I've been clinically depressed for years and have been on many different medications as well as seeing a psychiatrist and going through a course of behavioural modification, which was very effective. I will be on antidepressants for the rest of my life, and have found one which is very effective for me. If it means carrying around a bit of extra weight, so be it. I'll take happier over thinner any day. Report
Within a year 3 drastic events happened to me. I PLUNGED into a deep, dark depression which meant several hospitalizations hence make it #4 because I could not keep up with my job. A job I LOVED and was very good at. Depression though (plus from the car accident) I was no longer able to work. BINGO GOODBYE to my luxury apt.

I had the WORSE Dr EVER who is HAHAHA Now SUPPOSEDLY in CHARGE of the place. I have NO CLUE why. She kept telling me "YOU TAKE IT OR ELSE I'll PUT YOU BACK INTO THE HOSPITAL!" So I did. SIXTY lbs later on THAT med (Seroquel) the OLD BAT (I weighed 115 at the start at the end of THAT 1 I was at 145!) than she put me on risperdal and BAMB ANOTHER 30 LBS! So UP to 175 in ONLY A FEW MONTHS!! I got SMART and got RID of that old bat!!

I had been talking to someone I had met online and he recommended asking about an MAOI which I did ask my Dr. This is rarely used now since if you eat a WHOLE BUNCH of normal every day food, you can easily have a stroke or heart attack. I AGREED (We did a contract since it can be proved if you accidentally ate an item (often when eating out at any place, including family friends. A friend had a big spread for a bunch of us. THANKFULLY as I went to put the mashed potato into my mouth I thought and asked "What did you put in here?" It was cheese. A NO NO item! PHEW!!) it was necessary for a contract to be done.

In ONLy 3 days I felt so much better! In ONLY 3 weeks I felt as wonderful as I had used to. PHEW!!

If you are ever in a shrinks office, look around. I have. MOST of us where QUITE heavy. It could be that office, but I DOUBT it.

I will say that the MAOI Literally saved my life. I went on to gain and gain. Now it's FINALLY coming off. I've been OFF the MAOI now for almost 2 years an doing very well. Report
Very good advice for those that take antidepressants. Report


About The Author

Dean Anderson
Dean Anderson
Dean Anderson has master's degrees in human services (behavioral psychology/stress management) and liberal studies. His interest in healthy living began at the age of 50 when he confronted his own morbid obesity and health issues. He joined SparkPeople and lost 150 pounds and regained his health. Dean has earned a personal training certification from ACE and received training as a lifestyle and weight management consultant. See all of Dean's articles.