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SUEL1970 Posts: 154
7/30/10 6:12 P

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Intially my doctor put me on Metformin but I had major intestinal issues. Eventually, I was put on Glucxophage XR which I was able to tolerate with no intestinal issues, however, I always had a weird aftertaste in my mouth. I was taking 2000 mg a day. The Glucophage XR really didn't help me lose weight but it did regulate my periods. In November 2009, my endocrinologist switched me to Glumetza (1000 mg once a day)I was a little skeptical that a decrease in my meds would be beneficial. Well, I've had a regular period since switching to Glumetza and I no longer have a weird aftertaste.



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BELROSA's Photo BELROSA Posts: 697
7/27/10 4:06 A

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Unfortunately, the guidelines for prescribing metformin are largely ignored as a prescription is quick and easy to write and the things which really work for PCOS are either not common knowledge (D Chiro Inositol) or much harder to implement (low glycaemic load and index diet combined with the right kind of exercise.

There was a study published in a French Endocrinology Journal which looked at where Metformin is appropriate to prescribe. I've summarised it on my website: mypcos.info/1/treatments/pharmaceuti
ca
l/metformin/


Essentially, unless you are obese - BMI over 35, diabetic or with high fasting blood sugars (prediabetic) you shouldn't be on metformin - it's risks outweigh it's benefits.

I have a website with loads of PCOS info www.mypcos.info Please stop by!

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QUELEENDAH's Photo QUELEENDAH Posts: 132
7/26/10 11:39 A

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I am wondering if you are right. My Doc wants me to at least try Met ER to see if that makes a difference. She is hoping that only one pill a day versus trying to remember 3 pills a day when I am running 5 kids all over the place might make a difference.
I'm trying it just to rule it out. But if this doesn't work, I'm going to go a more natural route.I'm sure there is a naturopath somewhere around here!

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BELROSA's Photo BELROSA Posts: 697
7/12/10 5:40 A

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If you can lose weight without metformin, it sounds like you don't need it.

I have a website with loads of PCOS info www.mypcos.info Please stop by!

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ndividual.asp?gid=54257
QUELEENDAH's Photo QUELEENDAH Posts: 132
7/11/10 12:12 P

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I don't know what to think about Met. I feel better off of it.
I seem to have to take it regularly with a very strict IR diet for some time to see any kind of difference.

If I slip up at all, I go right back to being tired, constipated (yep, I'm one of those who get plugged up on met) and I get horrific headaches. I've always struggled with hypoglycemia. It seems a million times worse on met.

Being a really busy mom, it is really hard to be that consistent all the time just to see small results.

I have actually lost weight since I stopped taking it and am able to eat better and more consistently. Which helps with the hypoglycemia episodes, which helps with the energy levels.

It is interesting because Clomid actually helped me a lot when I was TTC.

I have an appt to see my doc soon. I was going to discuss either Met XR (I can do one pill a day!) or just trying diet and exercise.

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BELROSA's Photo BELROSA Posts: 697
7/9/10 8:55 P

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Metformin is supposed to increase insulin sensitivity and reduce the amount of carbohydrate absorbed from your food. It also reduces the amount of glucose your liver produces and increases the production of an enzyme involved in insulin signalling. If you have insulin resistance, this should give you more energy. If you have the hormonal problems associated with PCOS, this should eventually bring your hormones somewhat back in order - you may notice the return of an absent menstrual cycle or less facial and body hair, if these are symptoms you were suffering. If it were me, I would test whether it was doing anything by going off it for a month or two and taking note of how I feel if I were at all unsure whether it was doing any good. One doesn't want to be on medication if it's not working.

Scientists at the Saint Vincent de Paul hospital in Paris have recently published a study in the French medical journal Annales d’Endocrinologie which makes 8 recommendations regarding the prescription of metformin in women with PCOS.

1. Metformin is not efficient enough in order to regulate menstrual cycles.

2.Metformin is not efficient enough in order to treat hyperandrogenism.

3. Metformin should not be used as a first-line treatment in order to treat infertility. Clomiphene citrate (CC) is the reference treatment.

4. Metformin in addition to CC is not recommended as a second line treatment, after the failure of CC alone.

5. Metformin should not be used during pregnancy in non diabetic women with PCOS, in order to prevent the risk of gestational diabetes.

6. Metformin should be prescribed to PCOS women when they are diabetic, in order to prevent their cardiovascular risk, after lifestyle modification.

7. Metformin should not be used in PCOS non diabetic women in order to lose weight. Metformin should not be used in order to treat dyslipidemia in women with PCOS.

8. In PCOS women, without diabetes, but with fasting hyperglycemia or carbohydrate intolerance, metformin should be prescribed if: BMI is greater than 35.

Essentially it is saying that the side-effects outweigh the benefits for women with PCOS unless the condition is very severe and alternative methods have failed. If blood glucose control has totally broken down to the point of frank diabetes, or if the woman is very obese, with a BMI of 35 or greater. This would be equivalent to a weight of 225 lbs or just over 100 kg if you were 5′7″ tall or 170 cm.

Edited by: BELROSA at: 7/9/2010 (21:03)
I have a website with loads of PCOS info www.mypcos.info Please stop by!

Leader of Managing PCOS Naturally www.sparkpeople.com/myspark/groups_i
ndividual.asp?gid=54257
WE4PEPPERS's Photo WE4PEPPERS Posts: 67
7/9/10 11:37 A

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How does one gauge if the Metformin is working? I was put on Metformin after my third miscarriage and took it until my daughter was born. Then I took it again for the purpose of pregnancy and lost that pregnancy at 20 weeks. I immediately became pregnant again and lost that baby at 10 weeks. I am guessing my problems deal with more than just regulating my sugar. I am still on the Metformin although I am not trying to conceive anymore. So how do I know if it is doing anything for me? Thank you!

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TYEDYEDTURTLEZ Posts: 14
5/12/10 5:56 A

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What metformin does is help the liver process the excess sugar in your system, enabling your body to use the glucose instead of storing it, and your blood sugar going up. One of the theories with PCOS is that it goes hand in hand with Insulin Resistance aka pre-diabetes...which is why you're on Met. It doesn't cause you to lose weight. When you store glucose, you gain weight. I'm diabetic, and metformin no longer works for me to control my blood sugars. PCOS is one of those things that Dr's really do not understand. I suggest finding a good PCOS clinic or endocrinologist. They can help you with the weight issues, and fertility issues.

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TRYINAGAIN3's Photo TRYINAGAIN3 Posts: 1,597
4/28/10 9:56 A

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If you haven't had a period in a year your probably not ovulating. Metformin sometimes helps and it depends on the person. I'm only taking it while trying to have a baby as my doctors thought I would respond better to the fertility meds. It's worked and I do respond better since the meds that are helping me ovulate now didn't work without taking the metformin at the same time. You can get pregnant you may just need some help doing so. Metformin alone may not do the trick for you but there is other meds out there that will when your ready to start trying for a baby. emoticon

Edited by: TRYINAGAIN3 at: 4/28/2010 (09:57)



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BELROSA's Photo BELROSA Posts: 697
4/27/10 11:29 A

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My experience with Metformin is not typical, but I tried it and had a bad reaction to it - no GI symptoms, but it apparently damaged my liver. I went from having 6-8 periods a year, to no periods for 3.5 years and from being of normal weight to over those 3.5 years putting on 30 kg.

There are actually quite specific prescribing criteria that should be followed for metformin in PCOS, but they rarely are.

Scientists at the Saint Vincent de Paul hospital in Paris have recently published a study in the French medical journal Annales d’Endocrinologie which makes 8 recommendations regarding the prescription of metformin in women with PCOS.

1. Metformin is not efficient enough in order to regulate menstrual cycles.

2.Metformin is not efficient enough in order to treat hyperandrogenism.

3. Metformin should not be used as a first-line treatment in order to treat infertility. Clomiphene citrate (CC) is the reference treatment.

4. Metformin in addition to CC is not recommended as a second line treatment, after the failure of CC alone.

5. Metformin should not be used during pregnancy in non diabetic women with PCOS, in order to prevent the risk of gestational diabetes.

6. Metformin should be prescribed to PCOS women when they are diabetic, in order to prevent their cardiovascular risk, after lifestyle modification.

7. Metformin should not be used in PCOS non diabetic women in order to lose weight. Metformin should not be used in order to treat dyslipidemia in women with PCOS.

8. In PCOS women, without diabetes, but with fasting hyperglycemia or carbohydrate intolerance, metformin should be prescribed if: BMI is over 35.

Essentially it is saying that the side-effects outweigh the benefits for women with PCOS unless the condition is very severe and alternative methods have failed. If blood glucose control has totally broken down to the point of frank diabetes, or if the woman is very obese, with a BMI of 35 or greater. This would be equivalent to a weight of 225 lbs or just over 100 kg if you were 5′7″ tall or 170 cm.

www.ncbi.nlm.nih.gov/pubmed/20079483

Not everyone with PCOS has infertility problems. I have had no trouble falling pregnant at all - in fact you only have to look at me the wrong way and I'm pregnant! (Joking - sort of). Try not to worry too much about it ... get lots of exercise, don't eat high GI carbs, eat a healthy diet and see what happens. There's no point in worrying about something that may not be an issue anyway :)

All the best.



Edited by: BELROSA at: 4/27/2010 (11:32)
I have a website with loads of PCOS info www.mypcos.info Please stop by!

Leader of Managing PCOS Naturally www.sparkpeople.com/myspark/groups_i
ndividual.asp?gid=54257
MAJOOD85's Photo MAJOOD85 Posts: 935
4/27/10 11:14 A

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So my doctor put me on metformin for my PCOS... unfortunately... I have been on it since June of last year... and i still see no results what so ever... My doc saw that I had lost some weight... so he didnt want to take me off the metformin... but i dont think its helping me at all... yet he insists that i stay on it... has anyone been on metformin but seen no results? One thing i am worried about is that i am getting engaged this summer... and i know pcos causes people not to get pregnant... and im scared and worried that since i havevn't had my period in over a year... that i wont be able to have kids... and im just worried i guess. Do you guys that have PCOS and have tried metformin and hasnt worked been able to get pregnant?

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