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GRANDWORLD Posts: 2
2/19/10 6:25 P

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I usually exercise quite a bit but I didn't exercise as much when I lost the 30 pounds. I didn't have as much energy to exercise. I still did some running on my treadmill maybe 30 min running (around 3 miles) 3 times a week. The loss of weight was pretty effortless but I did eat very small portions at regular intervals. My appetite was really low. When I say small portions I mean about 3-4 tablespoons of food or the size of 1-2 chinese dumplings for a meal. The metformin also meant if I had anything slightly sugary I got diarrhea.

Edited by: GRANDWORLD at: 2/21/2010 (10:43)
WVMOMOF2's Photo WVMOMOF2 Posts: 10
2/19/10 5:30 P

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This is all really interesting. I haven't had the chance to talk with anyone who suffers from PCOS. I was first prescribed 500mg/twice a day and after 2 months was upped to 1,000/twice a day. Is that alot? All the talk about liver damage really scares me. I also haven't had a period yet. My endo talks about putting me on bc pills but I lost alot of hair when I was on them before.

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ANGIE294 Posts: 9
2/17/10 12:57 P

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When you lost the 30lbs how much did you exercise aside from the side effects of the metformin?

GRANDWORLD Posts: 2
2/16/10 3:49 P

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I have been on metformin 3 X 500 mg tablet a day (1500) for about 2 years now. It has regulated my periods down from about every 6 weeks to 3/4 months to pretty regular 6 week cycle and from when I ovulate I can predict my period pretty acurately. In terms of PCOS symptoms I have irregular periods, 'waxy skin' and insulin resistence. I don't have any excess hair etc. There seem to be different types of PCOS. Metformin helped with my insulin resistence (I could eat bread again) and period regularity and even made me feel more feminine and my skin looked better etc. It made me realize how many of my lifetime conditions where to do with PCOS. I started on 2X500 mg as at first there are a lot of symptoms to adapt to - loose bowels and stomache ache, tiredness etc. But after awhile you adapt and I went up to 1500 a day and my periods started to regulated. The diarrhea and appetite reduction helped me lose 30 pounds.

However, two years later the effects does ease off after awhile and now the weight is starting to creep back up (I am now up to 165pds and back in my fat jeans). I think the metformin has been great but I have never gone off it. I did not take any other drugs - just watching diet trying to do low carbs.

ANGIE294 Posts: 9
2/9/10 4:39 P

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I have started taking Metformin 500mg/twice a day and it has me feeling extemely tired and not to mention I get nauseated and bloated. I hope this medication works and helps with weight loss and pcos.

BELROSA's Photo BELROSA Posts: 697
1/29/10 7:31 P

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Hi Dana,

I was speaking with a doctor friend of mine the other day who also happens to have PCOS and mentioned the difficulties I had with metformin (similar to your experience). She suggested that it was likely liver damage from the metformin - it's a well known side effect. I don't know why I didn't think of it myself ... I warn everyone else about it, and the symptoms fit. Unfortunately, I just stopped taking it, I didn't go and get a liver function test, so I'll never know for certain.

It's interesting to note that DCI-IPG is produced in the liver and metformin has an effect on that process. It was only after (and immediately after) I took metformin that I totally lost control of my weight and started to suffer from a range of PCOS symptoms rather than just irregular periods.

Oral contraceptive pills are no longer recommended for treating PCOS - they make the underlying metabolic dysfunction which causes the symptoms of PCOS worse, whilst masking the symptoms.

mypcos.info/1/treatments/pharmaceuti
ca
l/ocp


So ... please go and have your liver enzymes checked and seriously consider going off BCPs ... the science does not back up their use, in fact it contradicts it. It has been theorized that long term use of BCPs may actually be causing PCOS in some women.

I have a website with loads of PCOS info www.mypcos.info Please stop by!

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DANADORNBURGH's Photo DANADORNBURGH Posts: 54
1/29/10 6:18 A

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Interesting post. I tried Metformin this past summer and spent the summer feeling like I got hit by a bus. Nausea, and fatigue, fatigue like I never experienced. I gave it several weeks and deterimed it was not for me. Doc put me on low dose BC pills ( I don't want to be on them, never used them in my life). I will explore this. thanks for chatting about it!

Life is Good
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Never lose faith,
Never back down."


BELROSA's Photo BELROSA Posts: 697
1/5/10 10:02 P

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I have tried both myo-inositol and d-chiro inositol and have found DCI to be much more effective. I've added myo-inositol back in now, as I hear that they work well together and whilst there are a lot more clinical studies supporting DCI than Myo-I, there are still a couple of studies which have found favourable results with Myo-I. And as you pointed out, it's bucket loads cheaper, although you do need to take a lot more of it.

I have actually started importing and retailing DCI myself as I could not afford to buy it retail from the US. I sell it for $30 AUD ($27.40 USD) for 18g, and discount up to 16% for bulk orders - buying 200 gm at once for $AUD 280. I am the cheapest retailer of DCI in the world at present to the best of my knowledge and believe I have actually caused the other retailers to lower their prices, which I'm pretty chuffed about. I'd like to get the price as low as possible, if I manage to get the turnover required to achieve it.

Dosage for DCI is best calculated based on weight (as most things ideally are really). 20 mg per kg of bodyweight has given the quickest and best clinical results, but as little as 10mg /kg can be used for maintenance in my experience. I am still taking 20mg/kg.

My website is in my signature and there is a link in the top right hand corner in a little text box to the DCI information. If you go to the tab "What is PCOS?" and go to What Causes PCOS, there is also more information about DCI as it seems to be a really integral part of the disease process. The chemistry is very interesting.

The regular inositol I buy from iherb.com - Healthy Origins brand powder for $12.99 USD for 8 oz or 227g. I take a teaspoon 1-3 times a day. Be sure to work up from a small amount though as this stuff has a few side effects - nausea, diarrhoea, headache etc - if you take a full dose from the get go. I think I started with 1g three times a day and worked my way up from there.


I have a website with loads of PCOS info www.mypcos.info Please stop by!

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ndividual.asp?gid=54257
CAH-RD's Photo CAH-RD Posts: 1,152
1/5/10 9:45 P

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I've been looking more into that lately and was actually considering taking it. I was looking more into the regular inositol as I hear that's working for a lot of people as well and it's a LOT cheaper. Where do you get your powder and how much does it cost? I'm strongly considering this next.

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BELROSA's Photo BELROSA Posts: 697
1/5/10 8:11 P

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I usually work with my patients to get them off Metformin as the severity of the side effects doesn't seem warranted when you consider the number of viable alternatives around with little to no side effects.

The most promising thing I've found is d-chiro inositol in combination with Manganese. I've got some interesting research on it if you want to email me I'll forward it to you. anne @ mypcos.info - just take out the spaces.

DCI is what got me having a regular cycle again. I'd been amenorrhoeic for 3.5 years and 4 weeks after I started taking DCI (initially from food sources, but I'm on the powder now) I began menstruating again and apart from a couple of hiccoughs when I've not taken it, my cycle has been pretty regular.

I have a website with loads of PCOS info www.mypcos.info Please stop by!

Leader of Managing PCOS Naturally www.sparkpeople.com/myspark/groups_i
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CAH-RD's Photo CAH-RD Posts: 1,152
1/5/10 6:00 P

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Well, overall I want to get have regular cycles and ovulate, but if I can decrease hirtuism in the process that'd be great too.

I'll be seeing my OB/GYN on Thursday. I'm thinking she'll up it to 1000, but I'm going to ask to work up to at least 1500, which is considered therapeutic dose.

I've never had a patient on as little as 500mg unless they were just working up, but I see DM patients moreso than PCOS.

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DIVA26's Photo DIVA26 Posts: 3,948
12/4/09 11:10 A

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I am on 500 mg twice a day and got a normal one this month. My first month using it. Is that what you are asking?

Life is wonderful. Live it to the fullest.


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BELROSA's Photo BELROSA Posts: 697
12/3/09 10:22 P

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I have several patients who have used doses of 250 mg - 750 mg metformin (always in combination with exercise and appropriate diet) to control PCOS. Control means different things for different women, though. What are your goals? Which symptoms are you trying to ameliorate?

I have a website with loads of PCOS info www.mypcos.info Please stop by!

Leader of Managing PCOS Naturally www.sparkpeople.com/myspark/groups_i
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CAH-RD's Photo CAH-RD Posts: 1,152
12/3/09 9:50 P

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I was started on 500mg met daily a few weeks back - about 3-4 weeks. I had AF (which I already knew was coming shortly after I started the Met - not caused by the met though).

Now, I almost feel kind of like I might O. And tonight when I wiped (sorry if TMI) I had a LOT (and I mean LOT!) of EWCM. This is CD 14 for me, so it'd be SUPER odd if I actually O'd right about when I was supposed to.

Has anyone else O'd with just 500mg??? I've pretty much only heard that most need 2000mg/daily to do anything.

I'm also curious if it's because I'm not overweight, I've started exercising, and my AF's weren't THAT irregular (I never went more than 5 months without them)...

Any thoughts?

I know I just need to wait it out, but I'm hoping that this is it for me and perhaps I won't even need to increase my dose. Just wishing though...

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