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MANDIEW13 SparkPoints: (0)
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7/20/11 12:41 P

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I am seeing a specialist in Indy, I was diagnosed after taking a round of anti-virals after a needlestick at work. I am going in September 2 for a sacral stimulator. Anyone have any comments or luck with this procedure? I am tired of being sick. I have lost 30 lbs in one yr. dealing with sickness. I fight to stay at 100lbs. Any advise?

CRAFTLADY8 Posts: 18
5/23/11 12:05 P

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I am recently diagnosed with Gastroparesis. I too have just starting using Domperidome. I have to mail order through a Canadian Pharmacy. It has worked wonders. I was on Reglan before and all I wanted to do is sleep and felt like I was always in a fog. Can't do that at work. Since Domperidome, I feel somewhat back to normal. When I forget 1 dose (I have been instructed to take 4 per day). I can tell the difference, stomach back up. I watch what I eat, stay away from fried foods and don't eat a lot at one time. If you have not tried Domperidome, you should.

 current weight: 160.0 
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5/15/11 3:03 P

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The part where they say currently there is no safe treatment for GP seems weird to me. I've been on Domperidone for over a year and it helps alleviate my symptoms A LOT. Other then tender breasts I dont have any other symptoms from the medication. I know its not available in the U.S. but its considered a safe medication here in Canada.

 current weight: 131.2 
NIKEGIRL1967's Photo NIKEGIRL1967 Posts: 478
11/11/10 2:47 P

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Hey, Lucky...thanks for the info on the new drug...I went to see my GI doc after the stent was pulled out in the middle of October; he flat-out told me that, at this point, there is nothing else we can try for the GP...he told me to work on the stress in my life...I said "Doc, I am am the only female in an office that is in the financial services industry; more sleep and less stress is not in my immediate future!"..LOL!

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10/25/10 10:51 A

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Thanks for the info, Lucky.


 Pounds lost: 83.0 
LUCKY-13's Photo LUCKY-13 Posts: 11,837
10/19/10 5:53 A

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October 18, 2010 05:01 AM Eastern Daylight Time
Tranzyme Pharma to Present TZP-102 Phase 2 Data Showing Decrease in Severity of Symptoms of Gastroparesis

Oral Presentation During the Plenary Session for Functional GI Disorders at the 2010 American College of Gastroenterology Meeting (ACG) in San Antonio, TX October 20, 2010

RESEARCH TRIANGLE PARK, N.C.--(BUSINESS WIRE)--Tranzyme Pharma announced today that John Wo, MD, Professor of Medicine and Director, Clinical Research, Division of Gastroenterology, Hepatology and Nutrition, University of Louisville, Louisville, KY, will present preliminary TZP-102 Phase 2 data at this year’s ACG annual meeting. The event is being held at the Henry B. Gonzalez Convention Center in San Antonio TX, October 15-20, 2010. Professor Wo is scheduled to speak on Wednesday, October 20th at 8:50am in Ballroom C1.

“An orally administered ghrelin agonist (TZP-102) decreases the overall severity of symptoms of diabetic gastroparesis (GP): Phase 2 Proof of Concept Study – Preliminary results”

The presentation entitled, “An orally administered ghrelin agonist (TZP-102) decreases the overall severity of symptoms of diabetic gastroparesis (GP): Phase 2 Proof of Concept Study – Preliminary results” will summarize the beneficial effects of TZP-102 on the multi-component gastroparesis symptom complex.

Gastroparesis, a syndrome dominated by early satiety, postprandial fullness and nausea, disrupts daily quality of life and, in severe cases, may require hospitalization. Gastroparesis complicates in particular the management of patients with diabetes and overall, comprises an area of extreme unmet medical need. Currently, there are no safe and effective treatments for gastroparesis. Earlier prescription medications used to treat this condition were either withdrawn from the market or must carry a “black box” warning due to serious side effects.

About Tranzyme Pharma

Tranzyme Pharma is a clinical-stage drug development company that discovers and develops novel small molecule macrocyclic drugs for both acute care (hospital-based) and chronic indications with significant unmet medical needs. The Company's pipeline is derived from its proprietary drug discovery (chemistry) technology, MATCH™, and targets products for gastrointestinal motility, metabolic diseases and cancer supportive care.

Tranzyme has two corporate partnerships -- a broad drug discovery partnership with Bristol-Myers Squibb to discover, develop and commercialize novel drug candidates in multiple therapeutic areas, and a European licensing agreement with Norgine for the co-development of Tranzyme’s intravenous ghrelin agonist, ulimorelin.


Life's an adventure ... take it one step at a time and don't underestimate yourself! You're capable of more than you think you are! How do I know this? You're still here aren't you? That means you haven't given up!

 current weight: 208.0 
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