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6/12/11 12:30 A

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Liraglutide works somewhat similarly to Metformin, however, it is a daily injection rather than a tablet, increases the production of insulin (which may exacerbate some symptoms of PCOS) and may increase the risk of certain types of cancer.

As it is a very new drug, it has been placed on a cancer register for 15 years to determine whether it will increase the risk or not. It was found to increase a type of thyroid cancer in rats, however, the mechanism by which this happened may not translate into a risk for humans. Serum calcitonin levels (a biomarker for thyroid cancer) were found to be elevated in patients taking liraglutide, however, which would make me concerned about its potential to cause thyroid cancer.

Metformin is generally regarded as a very safe drug and some studies have actually found it lowers the risk of pancreatic and other cancers, though the mechanism by which it does so has not been elucidated yet.

If it were me, I would not be inclined to take the risks associated with such a new drug, which already has a shadow over it, in relation to cancer risks.

I have a website with loads of PCOS info Please stop by!

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6/11/11 7:39 A

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Of course it's a personal choice and I'm no doctor but maybe it's worth giving metformin a go if you're already on it and it agrees with you as that is also meant to aid weight loss, if you find that doesn't work so well for you then you could always give the other choices a go then.

Don't know about you but I hate needing/taking meds to help with anything, unfortunately we don't always have a choice! :( (My main goal, apart from losing weight is to lose most of my meds)

It's also worth looking at your exercise program (not sure what you do etc and not wanting to preach) but I find that is the most important thing for helping with many of my symptoms as well as the healthy eating of course. If you're not diabetic, eating like one really helps.

Hope this helps but talk it over with your doc/health care provider I'm sure they would prefer to know you are confident in your choices.

Take care and good luck, hope whatever you go with works for you!


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6/6/11 8:09 A

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Hey girls,

I have recently been diagnosed with PCOS after 6 years of not being able to get pregnant. I got pregnant when I were 15 years old (first time). My daughter is now almost 8! However, for 6 years I have been in a very loving and commited relationship in which we were hoping to add to our family. It just never happend =(

I went to the doctors to get the ball rolling. I was prescribed Metformin. 1000mg x 1 per day for the first week. 1500mg per day the 2nd week. Just upped it again too 2000mg! Having only maybe 3/4 periods per year - after starting Metformin a few weeks ago I have actually just started a period!

I have all of the symptoms connected to PCOS.. No period, acne (during times I would be due a period), over-weight and I do not ovulate!

My specialist has offered me the chance to take part in a weight loss sceme where I used a drug daily either Liraglutide/Placebo as I have been told once I lose weight the symptoms will be greatly minimized anyway. I'm a little unsure what to do next. Should I stick with Metformin or try the other drug which is said to have fantastic weight loss results!!

Any and all advice welcome please =)

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