Yes, I run into that occasionally, since I don't like using artificial sweeteners (I tend to use honey, maple syrup, and agave nectar). I recently searched online and found out that the Splenda in a bag that you buy for baking, you substitute 1 for 1 with sugar. So that was good news, an easy "reverse substitution."
They say that 2 egg whites is equivalent to 1 egg in cooking, but I haven't tried a reverse substitution there.
I think some of it is trial and error, since some ingredients (especially sugar and eggs) often have more than one function in cooking.
SparkPeople has a handy little substitution list, although it doesn't include artificial sweeteners:
www.sparkpeople.com/resource/
nutrition
_articles.asp?id=338
--Marsha
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