L-Carnitine claims to inhibit obesity, but there is very little evidence of its effectiveness.
Dihydroxyacetone (DHA), Pyruvate, and Dihydroxyacetone and Pyruvate (DHAP):
A few small studies suggest that these supplements may have modest effects on weight loss, but research is needed. Presently, no serious side effects have been reported.
Alli: For a detailed discussion of Alli, the first FDA approved weight loss pill available over the counter, click here.
Lecithin, Guar Gum, Psyllium Hulls, Chickweed, and Chitosan (Examples: Chito-Trim, Exercise in a Bottle, Fat Blocker—Chitosan Complex, Fat Grabbers, Fat Trapper, Fat Trapper Plus, Metabo Fat Blocker, Miracletab, Now Chitosan with Chromium):
These products claim to help break down fat so that it can be absorbed, emulsified, trapped, and eliminated by the body. There is currently no competent and reliable scientific research to support such claims.
Stress, Craving, and Appetite Controllers
White Bean Extract, White Kidney Bean Extract, Green Tea Extract, Chlorogenic Acid from Coffee, Banaba Extract, Phaseolus Vulgaris, Natural Bean Extract (Examples: Carb Blocker Triple Action, CarboGetic, Carbo Grabbers, Carb Shuttle, CarboVal, Extreme Carb Blocker, Maximum Strength Phase 2 Carb Blocker, Now Phase 2 Carb Blocker, Starch Blocker Plus, UltraCarb, Xenadrine CarboCurb):
These products claim to prevent the digestion and neutralization of sugar and carbohydrates, therefore reducing the calories available to the body. The undigested carbohydrates are carried to the intestine for elimination. These claims lack scientific research and are false and misleading.
Hoodia Gordonii: For years the South African San bush people have used the succulent plant, Hoodia gordonii, to stave off hunger during long hunts. A few preliminary and unpublished research studies indicate that there may be some type of appetite-suppressing mechanism from a molecule in Hoodia called P57. This molecule supposedly affects the hypothalamus of the brain to reduce appetite. Now this plant from the Kalahari Desert is being imported and made into Hoodia pills, tablets and capsules to supposedly help with hunger control for those trying to lose weight. However, there is no conclusive evidence to support these claims regarding appetite control and weight loss. For now, more evidence is needed to determine if Hoodia is effective for any clinical condition. Beyond that, there is plenty of fake Hoodia on the market. News reports suggest that some Hoodia products don't even contain any actual Hoodia.
Magnolia Bark, Korean Ginseng, Chromium Picolinate, and Chitosan (Examples: CarboGetic, CarboVal, Maximum Strength Phase 2 Carb Blocker, Miracle Tab, Now Chitosan with Chromium):