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Health A-Z

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Harvard Medical School

Symptoms

In general, blisters are round or oval bubbles of fluid under the skin that may be painful or itchy, or they may not cause any symptoms. Symptoms vary depending on the cause.

  • Irritation, burns and allergies Blisters caused by friction or burns are usually painful. Blisters resulting from eczema can be accompanied by redness, severe itching and small bumps on the affected skin.

  • Infections When blisters are caused by an infection, the symptoms depend on the type of infection. Examples include:

    • Bullous impetigo The affected skin can redden, and the blisters may burst easily.

    • Herpes simplex virus When herpes simplex type 1 is the cause, the tiny blisters commonly are known as fever blisters or cold sores. They typically appear on the lips. The affected skin may itch, tingle, swell and become red before the blisters appear. When the blisters eventually break, they leak fluid, and then painful sores develop. Herpes simplex type 2 is the most common cause of genital herpes, a sexually transmitted infection (although type 1 also can cause genital herpes). Generally, small red bumps appear before blisters develop in the affected area, typically the vaginal area or penis, the buttocks and thighs, or the anus. Other symptoms can include fever, muscle aches, headache and burning with urination.

    • Varicella zoster virus When this virus causes chickenpox, the infection starts with a diffuse, itchy rash that develops quickly into itchy blisters. Varicella zoster also can cause shingles (herpes zoster). People with shingles may experience small, painful blisters that usually erupt in a linear pattern along the length of an infected nerve.

    • Coxsackievirus Coxsackievirus A16 can cause a condition commonly called hand-foot-and-mouth disease, in which painful blisters often occur on the hands, on the soles of the feet and in the mouth.

  • Skin diseases Erythema multiforme typically causes blisters on the palms of the hands, the forearms, the soles of the feet, and on the mucous membranes in the eyes, nose, mouth and genitals. Other symptoms include fever, sore throat, cough and muscle pain. The autoimmune diseases (also known as bullous diseases because of the large blisters seen) vary in appearance as well. Dermatitis herpetiformis causes itchy, red bumps or blisters. Pemphigoid, an uncommon condition that primarily affects the elderly, results in large, itchy blisters, and pemphigus, an uncommon disease that tends to strike in middle age, causes blisters inside the mouth and on the surface of the skin. The blisters of pemphigus break easily and leave painful areas.

  • Medications Reactions to medications vary. In some cases, there is only an increased sensitivity to the sun, which can lead to blistering sunburn if the skin is exposed to the sun. In more severe reactions, such as TEN, blisters can involve larger areas of tissue, including parts of the respiratory passages and gastrointestinal tract, accompanied by fever and malaise (a generally sick feeling).

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From Health A-Z, Harvard Health Publications. Copyright 2007 by the President and Fellows of Harvard College. All rights reserved. Written permission is required to reproduce, in any manner, in whole or in part, the material contained herein. To make a reprint request, contact Harvard Health Publications. Used with permission of StayWell.

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