Treatment is different for the different forms of MODY. Drugs from the oral sulfonylurea class are usually effective for patients with MODY 1, 3, and 4.These drugs include glipizide (Glucotrol) and glyburide (Glynase Pres Tab, others).About 30% to 40% of patients with MODY 1 and MODY 3 will eventually need insulin to control their blood sugar levels. Insulin is generally taken by injection.
MODY 2 rarely requires drug or insulin therapy, and can usually be managed by exercise and diet alone. MODY 5 may require several different treatments because it causes other problems in addition to diabetes.
People with any type of MODY will respond better to treatment if they are not overweight or obese. Therefore, overweight and obese people should include losing weight as one of their treatment goals.