Risks and side effects of biotherapy include:
Redness or infection at the injection site
Flulike symptoms, such as:
Changes in blood pressure
Low levels of white (infection-fighting) blood cells
Infection, including TB, especially in people with prior exposure
Interferons may be associated with depression and suicidal thoughts.
Trastuzumab (Herceptin) can cause the heart to pump less vigorously leading to heart failure. Usually heart function will improve when the drug is stopped.