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The outlook for schizotypal personality disorder varies and depends on many factors, including the severity of the symptoms, the availability of support, how much the person's ability to function is impaired, and whether the person has depression or anxiety. If a person is willing and able to participate in treatment, the prognosis improves.

It may not be realistic to expect a person with schizotypal personality disorder to become very comfortable socially. However, some with this disorder do respond very well to treatment with medication. In the best case, people with schizotypal personality disorder can lead satisfying lives by finding suitable work, and enjoying relationships and leisure activities that are a good fit for their personality style.

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