For cases of mild antibiotic-associated diarrhea, try the following suggestions:
If you have more severe diarrhea due to a C. difficile infection, your doctor probably will stop your antibiotic treatment and prescribe an antimicrobial drug called metronidazole (Flagyl) to eliminate C. difficile. If metronidazole fails, an alternative medication such as vancomycin (Vancocin) may be used.
About 3% of people with C. difficile infection will become seriously ill, with high fevers, severe abdominal pain, and a complication called toxic megacolon (enlarged colon) that will show up on a computed tomography (CT) scan. These patients should be evaluated by a surgeon. If the surgeon is concerned that the intestine might develop a hole or leak (perforate), he or she will recommend emergency surgery to remove the affected portion of the colon.
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