The outlook for children with fragile X syndrome is better when the disease is diagnosed early. Among people with a full fragile X mutation, about half of females and almost all males have lifelong mental retardation. People with fragile X syndrome usually have a normal lifespan.
Fragile X carriers can have other symptoms. Among women with a permutation, 1 in 5 experiences premature ovarian failure. Among men and women with a permutation, there is an increased risk of another neurological problem called fragile X tremor-ataxia syndrome (FXTAS).