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Prognosis

The outlook for children with fragile X syndrome is better when the disease is diagnosed early. Among people with a full fragile X mutation, about half of females and almost all males have lifelong mental retardation. People with fragile X syndrome usually have a normal lifespan.

Fragile X carriers can have other symptoms. Among women with a permutation, 1 in 5 experiences premature ovarian failure. Among men and women with a permutation, there is an increased risk of another neurological problem called fragile X tremor-ataxia syndrome (FXTAS).

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From Health A-Z, Harvard Health Publications. Copyright 2007 by the President and Fellows of Harvard College. All rights reserved. Written permission is required to reproduce, in any manner, in whole or in part, the material contained herein. To make a reprint request, contact Harvard Health Publications. Used with permission of StayWell.

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