Contraindicated Drug Combination:
Clearly contraindicated in all cases and should not be dispensed or administered to the same patient:
POTASSIUM-SPARING DIURETICS/TACROLIMUS - Adverse reaction with both drugs
Action is required to reduce the risk of severe adverse interaction.
POTASSIUM SPARING DIURETICS/EPLERENONE -
SPIRONOLACTONE/MITOTANE - Decreased effect of the latter drug
POTASSIUM SPARING DIURETICS/POTASSIUM PREPS - Increased effect of the latter drug
Assess the risk to the patient and take action as needed.
POTASSIUM SPARING DIURETICS/DROSPIRENONE - Additive side effects from both drugs
SPIRONOLACTONE/DIGOXIN - Increased effect of the latter drug
POTASSIUM SPARING DIURETICS/ACE INHIBITORS; ARB'S - Adverse reaction with both drugs
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