Always take with a meal (not just a snack).
Foods that are fatty or sugary/starchy seem to set off the "side effects" (as does lettuce, for some reason).
Most people start off on 500 mg/day and increase by 500 mg every 2 weeks or so. Go by how your body feels. You may need to wait a bit longer if you are sensitive to it. Once you get above 1,000 mg/day, most people split their dosages (ie, 500 in am, 500 at lunch, 500 with supper, or just 1,000 in am and 500 in the evening).
If you are really sensitive to it, you can try the Extended Release version. People tend to do better on one or the other.
Remember to plan to eat 3 main meals and 2 - 3 healthy snacks/day, so you're eating every 2 - 3 hours. Metformin slows down how quickly your body can raise blood sugar between meals, so this really helps avoid low blood sugar.
With weight loss, it's more that Metformin "unlocks the ability to lose weight" rather than making you lose by itself. The good news, though, is that healthy lifestyle changes then have a good chance of actually WORKING! Personally, I find that I really struggle not to gain weight if I'm not taking my Metformin, but with it, if I "behave myself", I can actually lose!
The main thing to remember is that over 80% of us "cysters" have some form of Insulin Resistance. With IR, you can end up with extra insulin "floating around" and causing trouble! It can actually block the ability to burn fat, and promotes weight gain!!! The extra insulin also tends to trigger PCOS symptoms, which is why Metformin is given to treat PCOS. It helps the body use insulin better, which reduces the extra insulin "floating around", which then (in most of us) helps to reduce the PCOS symptoms and your body starts to re-balance itself.
There ARE a few of us who really don't have IR, but not too many. Thyroid issues seem to be a close second, and you can have both issues. Every body is different.
Take care, and HTH!!! Good luck!!!
DipMT, Hon (ACTM)
(Diploma in Massage Therapy, with Honours from the Atlantic College of Therapeutic Massage)
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