From what I have been told, over time, the Metformin can cause your liver to have some issues. I think it has to do with the way your body metabolizes the Metformin. It goes through your liver. Your liver works as sort of a filter and I guess it can take a toll after awhile. Some people have a major reaction to Metformin and it can cause (rarely) death.
That is one reason why the label says not to drink alcohol while taking it.
My liver enzymes are a little high. They say "borderline" and brush it off. A doctor should be checking your liver (blood test) at least every 6 months while on the medication.
I still think that the benefit outweighs the risks at this point. Given the information, Metformin is a drug and we should all remember that it isn't as mild as taking an over the counter pain reliever or something. Heck, even Tylenol has been shown to cause liver issues now that I think about it!
All things in moderation! My desire is to lose weight and no longer take this medication. I won't stop taking it until I know my body can take care of itself without the assistance of Metformin.
Not sure if this helps! Some people just naturally have a "fatty" liver and that can cause higher than average liver enzymes. It is often hereditary.
I mostly use herbs - with no side effects - the only side effect was regulating my period and getting pregnant (Vitex - Chaste Tree).. I since the birth of my son have not been able to get my diet stable through the PCOS symtoms. I have a long complicated birth and diet story - but the short of it is first came herbs, then came Atkins diet, then 120 lbs gone and finally pregnant - ate crap foods - stopped all herbs and then baby/ from there on its getting back on track with a way whacked out thyroid and pcos. I'll get it though.
Most prescription drugs come with tons of side effects they find later - some fatal. I prefer the GREEN approach to my health - it's been working so far.
TO each their own - I like to keep all options open. I also do tons and tons of research.
I tend to stay away from herbal supplements because they're usually untested and the claims made are full of, quite frankly, lies. (Not to come down on you; this is a personal feeling)
The claim below that "D-Pinitol has now become one of the better studied insulin mimickers in the supplement industry" was the first one I looked at. I went and looked through a national database of published studies for D-Pinitol. I found only 35, most of which were chemistry studies on how to formulate the stuff, and just ONE STUDY on humans. 15 Koreans.
Better studied? With just one published result? That is a lie, pure and simple. If the companies have been doing studies, they haven't been publishing them in peer-reviewed journals, which generally means that the studies don't follow scientific principals.
Herbal supplements are totally unregulated by the government or by the industry itself. Each capsule can contain anywhere from 1% to 300% of the supposed active ingredient that the bottle claims it has. Most haven't been tested for interactions with other drugs (see all the women who got pregnant because St. John's Wort made their birth control fail!) and quite a few of them aren't safe to take. There's the thought that all-natural means healthy or easy, but remember: cyanide, arsenic, and snake venom are all natural. :P
Recent research has found this form of the vitamin B inositol may have profound insulin-like properties, which may explain its long use in traditional healing medicine for numerous diabetic-associated conditions. D-Pinitol has now become one of the better studied insulin mimickers in the supplement industry and is proving to be an excellent aid in improving glucose metabolism. Also noteworthy, it's been shown to help enhance the uptake of creatine without the use of high-calorie simple carbohydrates. Other names for D-Pinitol
D-chiro (+)-o-methyl inositol, Inzitol (trade name), Bougainvillea spectabilis Where to find D-Pinitol
D-Pinitol was traditionally used in Ayurvedic medicine. It's found in the leaves of a plant called Bougainvillea spectabilis. This plant's natural habitat is Brazil and Central and South Florida.
From what I understand, it's still hard to lose weight even with metformin. I have heard that some women tested in the normal range in their glucose tests, but were still insulin resistant. However, I wouldn't have a clue what else to look for. If you trust your doctor, and he/she is familiar with PCOS, I would think you could rest easy. If you want, the forums at soulcysters.net has a *ton* of information and research on just about everything PCOS-related.
I dream of pants that fit me at my waist *and* my hips in an affordable price range.
I asked my Dr about the metformin after my levels came back normal too. He said he did not want to recommend a medicine that was uneccesary and metformin would not help with my weight loss if I was not insulin resistant. He said it might appear to help at first as I would probably lose a few pounds because of the side effects. After talking at lenght with him we decided that it wasn't in my best interest to fill my body with medication when the best benefit would be watching my diet and exercising...something that still needs to be done with metformin.
So I just got my blood tests back. My A1c values were 5.2, which is below the threshold of 7 for possibility of diabetes. Fasting glucose was only 86, so I'm looking good there.
My TSH levels were a bit high and T4 low, which isn't surprising seeing as I couldn't take my medication for almost a week (pharmacy wouldn't give it to me!), so the doctor is upping my dosage a tiny bit.
I guess I'm both relieved (yay, no yucky-tasting medicine with bleh side effects) and sad (probably still going to be hard to lose weight). Should I advocate more strongly for the metformin?
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