As to why is the INR not affected. Coumadin and Lovenox are different in the way they effect the cascade of clotting and declotting enzymes in the blood and that are produced by the liver. One goes in the backdoor and one goes in the front door. Accomplish the same thing, just by a different route. This is why one affects the PT and one doesnt. Gets real technical real fast. Fascinating though.
The difference between lovenox and coumadin is their method and speed of action. They are both anticoagulants, but lovenox doesn't affect the Prothrombin number. Lovenox is vary fast acting and changes can be inacted quickly when post-surgery is a factor. The main thing is that coumadin can be swallowed (yeah) Lovenox is an injection and hurts!! The doctors are preferring lovenox pre & post surg for controllability of hemorraging and clotting. Food - Coumadin works by reducing the ability of the enzymes that are responsible for the regeneration of Vitamin K by the liver, to be formed. Reducing the clotting ability and all those protien factors that often are the culprits in genetic dx of clotting syndromes. The ingestment of vitamin K foods increases the K that our coumadin is trying to neutralize. Like a diabetic eating sugar. Has to have more insulin to compensate for the sugar her body can't deal with. I haven't heard of any research about the actual timing of the effect of high K foods. I do know it can take 3 days for an increase in coumadin to neutralize or take affect. It's not like diabeties in that they can manage it a little easier and quicker, eat a piece of cake, take another cc of insulin. We don't have that option due to the time delay of coumadin's effectiveness. I hope this helps a little.
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There has been are questions I have been asking and I have been wanting to know the answer for years. There always seemed to be mixed answers and since have never really gotten a straight answer to my questions, I am posting here.
Q. How do food and minerals effect the INR, in respect to a false reading?
Q. What are some of the various time tables that is takes for a food or mineral to change an INR reading?
Q. Why is an INR only effecting with warfarin and not Lovenox?
Q. If the relationship between food and blood-thinners can lead to morbidity, then why are people on blood thinners treated in the same respect as a diabetic?
These are just questions that, need answering for me, and maybe any of you that are on blood-thinners. They may be naive questions, but I would still like the answers....Thanks for listening...
Co-Leader The Phoenix Club Co-Leader Blood-thinners
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