General health information for general educational purposes only; not intended to replace personal consultation with a qualified healthcare professional.
Vitamin D from foods, supplements, self-taken and prescription drug sources should be adjusted/evaluated by a doctor after formal testing and interpretation of frequent blood calcium lab draws. Adequate calcium is necessary for vitamin D response. For the subject of vitamin D blood level it is called blood calcidiol level.
Vitamin D is a group of fat-soluble prohormones. pro•vi•ta•min; A vitamin precursor that the body converts to its active form through normal metabolic processes. Over 10 substances are in a group of steroid compounds, classified with vitamin D. Here are the more common known types in this class.
Vitamin D1 Ergocalciferol with lumisterol: Lumisterol is a compound that is part of the vitamin D family of steroid compounds. It is the stereoisomer of ergosterol made by the body; Patented lumisterol invention is in the field of cosmetics and medicinal chemistry. (connector-calcium mineral-to carry with lumisterol) synthetic versions are ‘NOT EXPLAINED TO LAY-PEOPLE’
Vitamin D2 ergocalciferol made from ergosterol (connector-calcium mineral-to carry): In foods where animal products are not desired, an alternative compound is ergocalciferol derived from the fungal sterol ergosterol a crystal, soluble in organic solvents, and vegetable oils, easily light/air damaged. Provitamin D2 is found in plants and yeast; one of the humanly usable sources. See this link for doctor prescribed brand names and great detail I learned from… www.drugs.com/pro/vitamin-d-ergocalciferol
l.html en.wikipedia.org/wiki/Cholecalciferol www.medicalnewstoday.com/articles/161618.p
Vitamin D3 Cholecalciferol (bile-calcium mineral-to carry) made from 7-dehydrocholesterol (hydrogen atom lost/bile-lipid) is the one other humanly used supplemented oral vitamin D. Processed for oral supplements, Cholecalciferol is produced industrially by the irradiation of 7-dehydrocholesterol extracted from lanolin found in sheep's wool. At high doses of long duration Cholecalciferol is poisonous. This is the most recommended type taken orally in America.
Vitamin D4 22-dihydroergocalciferol (22-two-water-connector-calcium mineral-to carry): a humanly ineffective form of Vitamin D. Other names include. See http://www.innvista.com/health/nutrition/vitamins/d.htm; has not been isolated from natural sources. (This web site is open to the public not locked to ‘doctor types only’ as some valuable tools are…)
Vitamin D5 sitocalciferol (situated-calcium mineral-to carry): Produced by irradiating 7-dehydrositosterol (7-hydrogen atom(s) lost water-situated-lipid).
Yes sun! 7-Dehydrocholesterol is a zoosterol that functions in the serum/blood plasma as a cholesterol precursor, and is converted to vitamin D3 in the skin, therefore: functioning as provitamin-D3. The presence of this compound in human skin enables humans to manufacture vitamin D3 from ultra-violet rays in the sun light, via an intermediate isomer pre-vitamin D3. The best sun tanning results do require the eye optic nerve to sense the light then the symphony of body functions and chemical actions and reactions respond through the brain and skin but that is covered in another article. It is also found in the milk of several mammalian species. This type was discovered by Nobel-laureate organic chemist, Adolf Windaus. Cholecalciferol (vitamin D3) is synthesized in the skin from 7-dehydrocholesterol under the action of ultraviolet B light. It reaches an equilibrium after several minutes depending on several factors including conditions of sunlight (latitude, season, cloud cover, altitude), age of skin, and color of skin. For a thorough in depth statement see…http://en.wikipedia.org/wiki/Cholecalciferol
The sun emits ultraviolet radiation in the UVA, UVB, and UVC bands. UVB exposure induces the production of vitamin D in the skin. The majority of positive health effects are related to this vitamin. It has regulatory roles in calcium metabolism (which is vital for normal functioning of the nervous system, as well as for bone growth and maintenance of bone density) immunity, cell proliferation, insulin secretion, and blood pressure. An overexposure to UVB radiation can cause sunburn and some forms of skin cancer. In humans, prolonged exposure to solar UV radiation may result in acute and chronic health effects on the skin, eye, and immune system. UVB destroys vitamin A in skin and direct DNA damage (free radicals and reactive oxygen species). The mutations that are caused by the direct DNA damage carry a UV signature mutation that is commonly seen in skin cancers of benign and malignant status. http://en.wikipedia.org/wiki/UV_radiation (The ozone layers help protect us.)
No Sun? (the potential for vitamin D hypersensitivity syndrome?)
25(OH)D levels of less than 25 ng/mL are found in people with two or more serious conditions: osteoporosis, heart disease, hypertension, autoimmune diseases, certain cancers, depression, chronic fatigue, or chronic pain. VDDS is more common among dark skinned races, the aged, and those who avoid the sun.
The Food Nutrition Board at the Institute of Medicine of The National Academies, which created the Dietary Reference Intakes (DRIs), take the following amounts of vitamin D if nothing is being synthesized (no sunlight exposure): I am not a doctor, therefore: follow this link to a source who can direct you to amounts of recommended value per gender, age, and body size. See… www.medicalnewstoday.com/articles/161618.p
Effected conditions and other terms
Calcifediol /calcidiol: common laboratory flagged search parameter of vitamin D body value during interpretation processing; 25-hydroxyvitamin D, abbreviated 25(OH)D; considered the best indicator of vitamin D status.
Calcitonon: A thyroid messenger that talks to bones and cartilage: too much in the system will shrink and damage hard tissues of bone and cartilage.
calcitriol receptor/ VDR: a receptor that could be damaged-missing-or non responsive.
hypercalcemia: thankfully, a rare extremely aggressive outcome of too much with other complications. There is not cure.
Hypervitaminosis vitamin D toxicity: caused by ingestion of large doses. See adverse changes
Vitamin D hypersensitivity syndromes are often mistaken for vitamin D toxicity. Vitamin D hypersensitivity syndrome, this rare syndrome occurs when abnormal tissue subverts the kidney's normal regulation of calcitriol production.
hydroxylation reactions: two separate required healthy steps are affected before any externally derived vitamin D sources can be body utilized. 1st) takes place in the liver (to 25-hydroxyvitamin D): 2) in the kidneys (to 1.25-dihydroxyvitamin D): a delay up to 24 hours occurs in the time between the vitamin D taken and the liver and kidneys synthesis action to a usable substance.
hypophosphatemia/ vitamin D-resistant rickets
(IU) International Unit, 1 mcg of vitamin D2 is equal to 40 USP Units.
Physiological doses: 5,000 IU per day, from all sources (ultraviolet from the sun; food and beverages whole or enriched sources of the diet; and additional powder, liquid, concentrated for hypodermic needle transferal shot, tablet, and capsule supplements). ( in my opinion if you are taking this much , doctor prescribed, please monitor often as ‘other doctors may give you something that may cause a conflicting or contrauprescibe a
Hypervitaminosis vitamin D toxicity: caused by ingestion of large doses. *See adverse changes.
Osteoporotic fractures (broken hips or other bones in seniors that can be prevented) Secosteriods; Chemically, the various forms of vitamin D are secosteroids; a molecule similar to a steroid but with a "broken" ring. Etym: L. Seco, to cut, _ steroid; Secosteroids are very similar in structure to steroids except that two of the B-ring carbon atoms (C9 and 10) of the typical four steroid rings are not joined, whereas in steroids they are. In humans, the most important secosteroid is Vitamin D.
Ideal limit and range
Sunlight, artificial light, oral or parental vitamin D, or a combination, is the text book description of goal for recommended restoration of circulating levels of 25(OH)D between 50–80 ng/mL., as read on lab results.
Cautions I am aware of:
Inactive Ingredients of some over-the-counter sources: 2-Ethoxyethanol, FD&C Blue #1, FD&C Yellow #5 (tartrazine may cause allergic-type reactions (in caramel flavoring too, it cause negative reactions in me, even in microscopic amounts/ parts-per-millions.), Gelatin (plant or animal source not mentioned), Glycerin, Soy Lecithin, Medium chain triglyceride, Purified water, Shellac glaze (again, food source used not mentioned, sometime natural polymer, sometimes synthetic), Titanium Dioxide.
Certain Formal prescription diuretics and vitamin D supplements could cause hypercalcemia to hypoparathyroid patients (I say; and some undiagnosed persons).
Vitamin D in excess of the recommended dietary allowance during normal pregnancy should be avoided.
Mineral oil interferes with the absorption of fat-soluble vitamins, including vitamin D preparations.
Elderly persons should use lesser amounts due to a greater frequency of decreased liver, kidney, or heart function, and of chronic disease or doctor prescribed special therapy.
Seasonal Affective Disorder (SAD) winter depression that is caused by decreased sunlight and is more prevalent at higher latitudes. Symptoms include feelings of depression, lethargy, fatigue, cravings for sweets and starches, headaches, sleep problems, and irritability.
Secosteriods (to cut-lipid); Chemically, the various forms of vitamin D are secosteroids; a molecule similar to a steroid but with a "broken" ring. L. Seco, to cut, _ steroid; Secosteroids are very similar in structure to steroids except that two of the B-ring carbon atoms (C9 and 10) of the typical four steroid rings are not joined, whereas in steroids they are. In humans, the most important secosteroid is Vitamin D.
Syndrome X/ insulin resistance, metabolic syndrome, glucose intolerance, prediabetes: A disease caused by your body's inability to make the most of the food you eat or failure to take in the essential daily nutrients from poor or limited choices or of fad diets increasing the risk for obesity, hypertension, nervous system disorders, eye disease, diabetes, cardiovascular disease, cancer, and Alzheimer's disease are all signs of malnutrition of which Vitamin D can be a part.
*Adverse changes to notice of too little or too much vitamin D, in all its many sources: from too much; from mixed reactions with other drugs; and/or from too little, as in malnutrition (or bodily malfunction causing inability to absorb it during digestion) resulting in one or more effects: osteoporosis-loss of minerals in adult bones; loss of mental clarity leads to mental retardation; kidney stress leads to irreversible renal insufficiency which may result in death; widespread calcification, including the heart, blood vessels, renal tubules, and lungs. Preventing and avoiding these negative results are part of why you must be seen by a doctor, who can test-retest to interpret the laboratory results; direct the strength and amounts of oral dosing if needed; and control possible other drug mixing; especially if you are being seen by more than one doctor with none to supersede over possible hazards.
Latin translations to help decipher the vitamin D types very simply!
Dehydro=losing one or more hydrogen atoms
Sterol=lipid, usually not water soluble
Ergo=connector, because of
Thank you to these web sites (and others, some that locked-up my computer) for the valuable information and wish to seek further reading details; please visit them. en.wikipedia.org/wiki/Vitamin_D www.vitamindcouncil.org/ renalfellow.blogspot.com/2009/01/vitamin-d
(my comment: this little beauty helps explain the foods with vitamin D) www.medicalnewstoday.com/articles/161618.p
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My own supplement is pharmaceutical grade, as pure as I need it, since dairy is off my list and my thyroid prescription meds caution much sunlight (I take this pill 24-7-there is no off day)
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