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TOPIC:   Researchers Discover How HIV Destroys Immune Cells 


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PHEBESS
PHEBESS's Photo Posts: 31,165
6/20/13 10:35 P

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DH was reading an article this morning where researchers have found that HIV cells will kill certain cancer cells - they're looking at using this as a last-resort treatment. Interesting concept. And definitely easier to live with HIV than cancer!

"Dance as if no one is watching."


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TWEETYKC00
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6/20/13 6:55 P

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Wow. If they can keep the t cells going, the body could really be in better shape! That is major!


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BIGPAWSUP
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6/20/13 3:11 P

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That's really cool!

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SEASONS_CHANGE_
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6/20/13 2:06 P

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NIH Scientists Discover How HIV Kills Immune Cells: Findings Have Implications for HIV Treatment

From U.S. National Institute of Allergy and Infectious Diseases

June 5, 2013

WHAT:
Untreated HIV infection destroys a personís immune system by killing infection-fighting cells, but precisely when and how HIV wreaks this destruction has been a mystery until now. New research by scientists at the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, reveals how HIV triggers a signal telling an infected immune cell to die. This finding has implications for preserving the immune systems of HIV-infected individuals.

HIV replicates inside infection-fighting human immune cells called CD4+ T cells through complex processes that include inserting its genes into cellular DNA. The scientists discovered that during this integration step, a cellular enzyme called DNA-dependent protein kinase (DNA-PK) becomes activated. DNA-PK normally coordinates the repair of simultaneous breaks in both strands of molecules that comprise DNA. As HIV integrates its genes into cellular DNA, single-stranded breaks occur where viral and cellular DNA meet. Nevertheless, the scientists discovered, the DNA breaks during HIV integration surprisingly activate DNA-PK, which then performs an unusually destructive role: eliciting a signal that causes the CD4+ T cell to die. The cells that succumb to this death signal are the very ones mobilized to fight the infection.

According to the scientists, these new findings suggest that treating HIV-infected individuals with drugs that block early steps of viral replication -- up to and including activation of DNA-PK and integration -- not only can prevent viral replication, but also may improve CD4+ T cell survival and immune function. The findings also may shed light on how reservoirs of resting HIV-infected cells develop and may aid efforts to eliminate these sites of persistent infection.

www.thebodypro.com/content/71845/nih-scien
tists-discover-how-hiv-kills-immune-ce
lls.html?ic=700100


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