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PHEBESS's Photo PHEBESS Posts: 32,447
3/8/13 11:36 P

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Well, I'm still sore and bruised at the incision area, but I have my strength and endurance back - so I'm feeling normal. Just careful of my right side!

Thank you for asking!

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WHOVIAN85's Photo WHOVIAN85 Posts: 861
3/8/13 6:35 A

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yes, that is good to know. How have you been phebes, are you recovering well from your surgery? I go in April to have mine(lump in stomach) looked at, it feels like it has gotten bigger but maybe that is just because I'm losing weight and I notice it more.

"The good things donít always soften the bad things ó but vice versa ó the bad things donít necessarily spoil the good things or make them unimportant."
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PHEBESS's Photo PHEBESS Posts: 32,447
3/8/13 1:41 A

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Amb3rkenji, the last stats I read said that for someone who is HIV+ and taking retrovirals, life expectancy is about 6 months less that if they weren't HIV+. That's it - six months less. So your husband has pretty much the same expectancy to see your grandkids as before. Good to know, isn't it?

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3/7/13 7:35 A

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It will happen. :)

"How far that little candle throws its beams! So shines a good deed in a naughty world."
~William Shakespeare


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WHOVIAN85's Photo WHOVIAN85 Posts: 861
3/7/13 6:57 A

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I hope they find a cure in our lifetime, I want my husband to see our grandkids someday.

"The good things donít always soften the bad things ó but vice versa ó the bad things donít necessarily spoil the good things or make them unimportant."
Doctor Who Series 5: Vincent and the Doctor
SW: 232
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SEASONS_CHANGE_'s Photo SEASONS_CHANGE_ SparkPoints: (84,500)
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3/7/13 6:52 A

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I agree. Not good news at all. At least it's been recognized so they can lay the groundwork to find something around this. It's amazing how much progress has been made.

We'll see a cure in our lifetime.

"How far that little candle throws its beams! So shines a good deed in a naughty world."
~William Shakespeare


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PHEBESS's Photo PHEBESS Posts: 32,447
3/7/13 6:11 A

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Wow that's depressing - though it explains why there seems to be an AIDS-related loss of cognitive functioning in some long-term survivors. Oy - and DH already had PML, a secondary infection seen mostly in HIV-AIDS patients, that is basically a brain infection. NOT a good combo!

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3/7/13 5:41 A

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The Brain as the Ideal Reservoir for HIV, Foiling Eradication Attempts

February 27, 2013

The Brain as the Ideal Reservoir for HIV, Foiling Eradication Attempts

With the blood-brain barrier preventing antiretrovirals (ARVs) from gaining easy access to its tissues, the brain provides a protected reservoir for HIV, where the virus develops brain-specific mutations that allow it to become more virulent against the central nervous system (CNS). Publishing their commentary and review of available literature in Current Opinion in HIV and AIDS, Australian scientists describe HIVís unique relationship with the brain.

HIV, they write, establishes a reservoir in the brain shortly after infection and causes neurocognitive dysfunction, a mild form of which continues notwithstanding treatment with ARVs. A reason for this may be that ARVs do not fully control the viral reservoir in the brain. The virus infects macrophage and astrocyte cells where it may find safe harbor for long periods thanks to the fact that these cells are some of the longest living in the body. During this time, the virus evolves to develop the capacity to infect cells with low CD4 expression, thus amplifying its ability to damage the CNS.

There are concerns that attempting to eradicate the virus from various reservoirs, but not from the brain, could result in a mutated form of the virus from the brain later replenishing the other reservoirs. Furthermore, the refurbished immune system may then attack the virus in the brain, which could lead to devastating encephalitis (swelling of the brain). Eradication efforts, therefore, should attempt to prevent HIVís entry into the brain or to find ways to keep the virus in a latent state there, considering that purging the virus from the brain may not be feasible with currently available approaches.

www.aidsmeds.com/articles/brain_rese
rv
oir_1667_23545.shtml


"How far that little candle throws its beams! So shines a good deed in a naughty world."
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