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WOUBBIE's Photo WOUBBIE Posts: 13,360
2/26/13 9:56 A

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Wow. Nice catch! I did a little googling and came up with the actual abstract of the article (last paragraph).

Basically it's saying that they've located a number of gene locations that may determine the predilection for developing gout. Inhibins and activins are groups of proteins that regulate a whole host of body functions, but high up on the list is regulating metabolism and kidney function. I'd guess that it's a malfunction in kidney regulation that messes up blood uric acid concentration.

"Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from more than 140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations... Associations for many of the loci were of similar magnitude in individuals of non-European ancestry. We further characterized these loci for associations with gout, transcript expression and the fractional excretion of urate. Network analyses implicate the inhibins-activins signaling pathways and glucose metabolism in systemic urate control. New candidate genes for serum urate concentration highlight the importance of metabolic control of urate production and excretion, which may have implications for the treatment and prevention of gout."

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JIBBIE49's Photo JIBBIE49 Posts: 71,614
2/25/13 1:18 P

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