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IT*SNEVER2LATE's Photo IT*SNEVER2LATE Posts: 4,026
6/17/08 8:08 P

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I find this article about steroids in a Mayo clinic e-letter. I thought the section about tapering was interesting. Here's hoping that I haven't been on it long enough to get any nasty side effects/residuals.

www.mayoclinic.com/health/steroids/H
Q0
1431


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IT*SNEVER2LATE's Photo IT*SNEVER2LATE Posts: 4,026
6/14/08 2:51 P

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emoticon

Thanks,Janet,for the informative article. I take digestive enzymes with bromelain before my meals,but the dose is not very high.

Sounds like I should be taking it in larger doses between meals. That's a good thing to know.

Hope everybody is enjoying their weekend!
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6/14/08 12:54 P

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As your somewhat faithful gout researcher, I found this article about bromelain.

altmedicine.about.com/cs/herbsvitami
ns
a1/a/Bromelain.htm


Bromelain
From Cathy Wong,
Your Guide to Alternative Medicine.

What is Bromelain?

Bromelain is a mixture of enzymes found naturally in the juice and stems of pineapples. Called a proteolytic enzyme, bromelain is believed to help with the digestion of protein.

Some bromelain appears to be absorbed by the body intact, so it's also thought to have effects outside the digestive tract. In fact, bromelain is often marketed as a natural anti-inflammatory for conditions such as arthritis. It's one of the most popular supplements in Germany, where it is approved by the Commission E for the treatment of inflammation and swelling of the nose and sinuses due to surgery or injury.

Bromelain is typically extracted from pineapples and made into capsule or tablet form. Because it's able to digest protein, bromelain is available in some grocery stores as a meat tenderizer.

A topical form of bromelain is also being explored experimentally for burns.

When used for as a digestive aid, bromelain is usually taken with meals. When used for inflammatory conditions, practitioners typically recommend taking bromelain between meals on an empty stomach to maximize absorption.

Why Do People Use Bromelain

Surgery and Injuries

There is some evidence that bromelain supplements may reduce swelling, bruising, inflammation and pain after surgery and injury. In Germany, bromelain has been approved for these uses by the Commission E since 1993. Large, well-designed studies are needed, because not all studies have confirmed these results.

Sinusitis

Bromelain has been suggested as a complementary treatment for sinusitis. Preliminary studies suggest that it may help reduce congestion, improve breathing and suppress coughing. It's approved by the Commission E as a complementary treatment for nasal and sinus swelling and inflammation after ear, nose and throat surgery. A review of three small but well-designed previously published studies found that bromelain may help relieve sinusitis symptoms.

Digestion

Bromelain is a popular natural digestive aid due to it's ability to digest proteins. It's used for bloating, gas and other digestive symptoms and for conditions such as irritable bowel syndrome. Bromelain is often used alone or in combination with other enzymes such as lipase, which digests fats, and amylase, which digests starch. There is little research, however, on the safety or effectiveness of bromelain for digestion.

Osteoarthritis

Bromelain may help with mild pain associated with osteoarthritis. It's a common ingredient in nutritional supplements marketed as a natural pain remedy for arthritis. Large, well-designed studies are needed to see if it is effective and to find out about possible side effects.

Cancer

Bromelain and other proteolytic enzymes have been explored as a complementary treatment for cancer. Although there is some preliminary research, there isn't enough evidence at this time on the safety or effectiveness of bromelain for cancer. It should never be used in place of conventional treatment.

Side Effects and Safety Concerns

Some of the more common side effects of bromelain include indigestion, nausea and diarrhea. Other side effects may include vomiting, increased heart rate, drowsiness and abnormal uterine bleeding or heavy menstruation.

Bromelain has resulted in allergic reactions and asthma symptoms, including breathing problems, tightness in the throat, skin hives, rash or itchy skin. People with allergies to pineapples should avoid bromelain. Allergic reactions may also occur in people with allergies to latex, carrot, celery, fennel, rye, wheat, papain, bee venom or grass, birch or cypress pollens.

People with peptic ulcers should not use bromelain. People with other digestive disorders should consult a qualified healthcare professional before using bromelain.

Theoretically, bromelain may increase the risk of bleeding, so people with bleeding disorders and those taking medication that can increase the risk of bleeding should only use bromelain under the supervision of their physician. It should not be taken two weeks before or after dental procedures or surgery.

The safety of bromelain in pregnant or nursing women, children or people with liver or kidney disease isn't known.

Possible Drug and Herb Interactions

People taking "blood-thinners" (anticoagulant or anti-platelet medication), such as aspirin, warfarin (Coumadin), heparin, clopidogrel (Plavix), non-steroidal anti-inflammatory medications such as ibuprofen (Motrin, Advil), naproxen (Naprosyn, Aleve) should only use bromelain under a physician's supervision. It should also be used with caution by people taking herbs and supplements that are thought to increase the risk of bleeding, such as ginkgo biloba and garlic.

Studies suggest bromelain may also increase the absorption of other medications, such as:

- amoxicillin, tetracycline and other antibiotics

- chemotherapy drugs such as 5-fluorouracil and vincristine

- "ACE inhibitor" blood pressure medications such as captopril (Capoten) and lisinopril (Zestril)

- medications that cause drowsiness, such as benzodiazepines lorazepam (Ativan) or diazepam (Valium), some antidepressants, narcotics such as codeine, and barbituates such as phenobarbitol.


Sources:

Brien S, Lewith G, Walker AF, Middleton R, Prescott P, Bundy R. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM. (2006) 99.12: 841-850.

Brien S, Lewith G, Walker A, Hicks SM, Middleton D. Bromelain as a Treatment for Osteoarthritis: a Review of Clinical Studies. Evid Based Complement Alternat Med. (2004) 1.3: 251-257.

Updated: November 30, 2007



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IT*SNEVER2LATE's Photo IT*SNEVER2LATE Posts: 4,026
6/13/08 1:56 P

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I confidently affirm that the greater part of those who are supposed to have died of gout, have died of the medicine rather than the disease - a statement in which I am supported by observation.

-Thomas Sydenham

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IT*SNEVER2LATE's Photo IT*SNEVER2LATE Posts: 4,026
6/10/08 7:57 P

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Is anyone on chronic medication for their gout? As soon as my inflammation goes down,I'm supposed to start on Allopurinol. I really don't want to start on yet another drug,but since my kidneys aren't filtering,I need some way to get rid of the extra uric acid. My count was 12,and my Dr.said that was "quite high". It doesn't sound high! Anybody else have a high uric acid count,and,if so,how high was it?

How about natural remedies. I've heard that some people swear by tart cherries. Is their some concentrated tart cherry juice you mix with water and take every day? Any other natural remedies?

Sandy emoticon

Edited by: IT*SNEVER2LATE at: 6/10/2008 (19:56)
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IT*SNEVER2LATE's Photo IT*SNEVER2LATE Posts: 4,026
6/6/08 3:51 P

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Thanks,Janet!

I did not know about the new partner. The more info...the better! Have a good weekend.

Sandy

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JANEXA's Photo JANEXA SparkPoints: (107,505)
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6/6/08 3:29 P

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SP has a new partner, Revolution Health. Here is a good link that various people rated different gout medications.

www.revolutionhealth.com/drugs-treat
me
nts/rating/gout?view=condition


I have not looked at any other information about gout at the site, but it also has info about physicians in your area. I did a search for physicians, but mine was not listed. That's ok with me because I am very happy with mine.



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5/28/08 10:24 P

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Some info about prednisone from MedlinePlus. www.nlm.nih.gov/medlineplus/print/dr
ug
info/medmaster/a601102.html


Drug Information: Prednisone
(pred' ni sone)

Why is this medication prescribed?
Prednisone is used alone or with other medications to treat the symptoms of low corticosteroid levels (lack of certain substances that are usually produced by the body and are needed for normal body functioning). Prednisone is also used to treat other conditions in patients with normal corticosteroid levels. These conditions include certain types of arthritis; severe allergic reactions; multiple sclerosis (a disease in which the nerves do not function properly); lupus (a disease in which the body attacks many of its own organs); and certain conditions that affect the lungs, skin, eyes, kidneys blood, thyroid, stomach, and intestines. Prednisone is also sometimes used to treat the symptoms of certain types of cancer. Prednisone is in a class of medications called corticosteroids. It works to treat patients with low levels of corticosteroids by replacing steroids that are normally produced naturally by the body. It works to treat other conditions by reducing swelling and redness and by changing the way the immune system works.

How should this medicine be used?
Prednisone comes as a tablet, a solution (liquid), and a concentrated solution to take by mouth. Prednisone is usually taken with food one to four times a day or once every other day. Your doctor will probably tell you to take your dose(s) of prednisone at certain time(s) of day every day. Your personal dosing schedule will depend on your condition and on how you respond to treatment. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take prednisone exactly as directed. Do not take more or less of it or take it more often or for a longer period of time than prescribed by your doctor.

If you are taking the concentrated solution, use the specially marked dropper that comes with the medication to measure your dose. You may mix the concentrated solution with juice, other flavored liquids, or soft foods such as applesauce.

Your doctor may change your dose of prednisone often during your treatment to be sure that you are always taking the lowest dose that works for you. Your doctor may also need to change your dose if you experience unusual stress on your body such as surgery, illness, infection, or a severe asthma attack. Tell your doctor if your symptoms improve or get worse or if you get sick or have any changes in your health during your treatment.

If you are taking prednisone to treat a long-lasting disease, the medication may help control your condition but will not cure it. Continue to take prednisone even if you feel well. Do not stop taking prednisone without talking to your doctor. If you suddenly stop taking prednisone, your body may not have enough natural steroids to function normally. This may cause symptoms such as extreme tiredness, weakness, slowed movements, upset stomach, weight loss, changes in skin color, sores in the mouth, and craving for salt, and may cause death. Call your doctor if you experience these or other unusual symptoms while you are taking decreasing doses of prednisone or after you stop taking the medication.

Other uses for this medicine
Prednisone is also sometimes used with antibiotics to treat a certain type of pneumonia in patients with acquired immunodeficiency syndrome (AIDS). Talk to your doctor about the risks of using this drug for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?
Before taking prednisone,

- tell your doctor and pharmacist if you are allergic to prednisone, any other medications, or any of the inactive ingredients in prednisone tablets or solutions. Ask your doctor or pharmacist for a list of the inactive ingredients.

- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: amiodarone (Cordarone, Pacerone); anticoagulants ('blood thinners') such as warfarin (Coumadin); certain antifungals such as fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral) and voriconazole (Vfend);aprepitant (Emend); aspirin; carbamazepine (Carbatrol, Epitol, Tegretol); cimetidine (Tagamet); clarithromycin (Biaxin, in Prevpak); cyclosporine (Neoral, Sandimmune); delavirdine (Rescriptor); diltiazem (Cardizem, Dilacor, Tiazac, others); dexamethasone (Decadron, Dexpak); diuretics ('water pills'); efavirenz (Sustiva); fluoxetine (Prozac, Sarafem); fluvoxamine (Luvox); griseofulvin (Fulvicin, Grifulvin, Gris-PEG); HIV protease inhibitors including atazanavir (Reyataz), indinavir (Crixivan), lopinavir (in Kaletra), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), and saquinavir (Fortovase, Invirase); hormonal contraceptives (birth control pills, patches, rings, implants, and injections); lovastatin (Altocor, Mevacor); medications for diabetes; nefazodone; nevirapine (Viramune); phenobarbital; phenytoin (Dilantin, Phenytek); rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, in Rifamate); sertraline (Zoloft); troleandomycin (TAO); verapamil (Calan, Covera, Isoptin, Verelan); and zafirlukast (Accolate).Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

- tell your doctor what herbal products you are taking or plan to take, especially St. John's wort.
tell your doctor if you have an eye infection now or have ever had eye infections that come and go and if you have or have ever had threadworms (a type of worm that can live inside the body); diabetes; high blood pressure; emotional problems; mental illness; myasthenia gravis (a condition in which the muscles become weak); osteoporosis (condition in which the bones become weak and fragile and can break easily); seizures; tuberculosis (TB); ulcers; or liver, kidney, intestinal, heart, or thyroid disease.

- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking prednisone, call your doctor.

- if you are having surgery, including dental surgery, or need emergency medical treatment, tell the doctor, dentist, or medical staff that you are taking or have recently stopped taking prednisone.

You should carry a card or wear a bracelet with this information in case you are unable to speak in a medical emergency.

- do not have any vaccinations (shots to prevent diseases) without talking to your doctor.
you should know that prednisone may decrease your ability to fight infection and may prevent you from developing symptoms if you get an infection. Stay away from people who are sick and wash your hands often while you are taking this medication. Be sure to avoid people who have chicken pox or measles.

- Call your doctor immediately if you think you may have been around someone who had chicken pox or measles.

What special dietary instructions should I follow?
Your doctor may instruct you to follow a low-salt, high potassium, or high calcium diet. Your doctor may also prescribe or recommend a calcium or potassium supplement. Follow these directions carefully.

Talk to your doctor about eating grapefruit and drinking grapefruit juice while you are taking this medication.

What should I do if I forget a dose?
When you start to take prednisone, ask your doctor what to do if you forget to take a dose. Write down these instructions so that you can refer to them later. Call your doctor or pharmacist if you miss a dose and do not know what to do. Do not take a double dose to make up for a missed dose.

What side effects can this medication cause?
Prednisone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

headache
dizziness
difficulty falling asleep or staying asleep
inappropriate happiness
extreme changes in mood
changes in personality
bulging eyes
acne
thin, fragile skin
red or purple blotches or lines under the skin
slowed healing of cuts and bruises
increased hair growth
changes in the way fat is spread around the body
extreme tiredness
weak muscles
irregular or absent menstrual periods
decreased sexual desire
heartburn
increased sweating

Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:

vision problems
eye pain, redness, or tearing
sore throat, fever, chills, cough, or other signs of infection
seizures
depression
loss of contact with reality
confusion
muscle twitching or tightening
shaking of the hands that you cannot control
numbness, burning, or tingling in the face, arms, legs, feet, or hands
upset stomach
vomiting
lightheadedness
irregular heartbeat
sudden weight gain
shortness of breath, especially during the night
dry, hacking cough
swelling or pain in the stomach
swelling of the eyes, face, lips, tongue, throat, arms, hands, feet, ankles, or lower legs
difficulty breathing or swallowing
rash
hives
itching

Prednisone may slow growth and development in children. Your child's doctor will watch his or her growth carefully. Talk to your child's doctor about the risks of giving prednisone to your child.

Prednisone may increase the risk that you will develop osteoporosis. Talk to your doctor about the risks of taking prednisone and about things that you can do to decrease the chance that you will develop osteoporosis.

Some patients who took prednisone or similar medications developed a type of cancer called Kaposi's sarcoma. Talk to your doctor about the risks of taking prednisone.

Prednisone may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/MedWatch/index.html] or by phone [1-800-332-1088].

What storage conditions are needed for this medicine?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to prednisone.

If you are having any skin tests such as allergy tests or tuberculosis tests, tell the doctor or technician that you are taking prednisone.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand name(s):
Prednisone Intensol®
Sterapred®
Sterapred® DS


Last Revised - 04/01/2006
Last Reviewed - 08/01/2007





American Society of Health-System Pharmacists, Inc. Disclaimer - http://www.nlm.nih.gov/medlineplus/ashpdis
claimer.html


The MedMaster™ Patient Drug Information database provides information copyrighted by the American Society of Health-System Pharmacists, Inc., Bethesda, Maryland Copyright© 2004. All Rights Reserved.


Look into your heart, work towards your dreams, and they will come true.

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;.•.♥Janet F. in N. California♥.•;.•.
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IT*SNEVER2LATE's Photo IT*SNEVER2LATE Posts: 4,026
5/26/08 7:58 P

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This is a good reference for new & old gout medications,and their side effects.
--------------------------------------

www.webmd.com/a-to-z-guides/gout-med
ic
ations


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IT*SNEVER2LATE's Photo IT*SNEVER2LATE Posts: 4,026
5/26/08 7:51 P

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How Is Gout Treated?

Medicine that lowers uric acid levels, such as ALLOPURINOL(Zyloprim) or PROBENECID (Benemid), also may be prescribed to help prevent a gout attack. Low doses of COLCHICINE are also used to prevent attacks. These drugs are recommended for people who have had multiple attacks of gout, kidney stones due to uric acid, or tophi. The goal of lowering the blood uric acid is to slowly dissolve deposits of uric acid in the joint.

Sudden lowering of the uric acid level may cause an attack of gout. To prevent attacks in people who are taking uric acid-lowering drugs, PREDNISONE, colchicine or an NSAID is temporarily prescribed.

In addition, uric acid-lowering therapy (with allopurinol or probenecid) is not started during a gout attack, since sudden lowering of the uric acid can cause a new attack or prolong an existing one.

What Are the Side Effects of Gout Medicine?

Upset stomach, indigestion and headaches are the most common side effects of anti-inflammatory NSAIDs. Taking these medications with food can help reduce stomach upset. NSAIDs also can cause vomiting, constipation, ulcers, bleeding in the stomach, irritation of the liver, and kidney damage, although these side effects are less common. NSAIDs should be avoided in those with a history of bleeding stomach ulcers and weak kidneys.

Side effects of corticosteroids include weight gain, increased appetite and mood swings. Corticosteroids can have serious side effects when taken for a long period of time. Possible serious side effects include osteoporosis (thinning of the bones), diabetes, high blood pressure, cataracts, and decreased resistance to infection.

Possible side effects from COLCHICINE include diarrhea, nausea and abdominal cramps. In high doses, colchicine can cause kidney failure, seizures, and failure of the bone marrow, which leads to low blood counts. High doses of colchicine should be used with caution, especially in patients with kidney or liver disease.

The most common side effects of allopurinol and probenecid are upset stomach, diarrhea, headache or dizziness, and a skin rash. The development of a rash while taking allopurinol should be reported to your physician immediately; the drug will likely need to be stopped.

Not everyone will develop side effects from gout medications. How often any side effect occurs varies from person to person. The occurrence depends on the dose, type of medication, concurrent illnesses or other medications the person may be taking.

Some side effects are more serious than others. Before any medication is prescribed, your doctor will discuss with you the potential benefits and risks of taking the medication


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IT*SNEVER2LATE's Photo IT*SNEVER2LATE Posts: 4,026
5/26/08 7:34 P

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HERE'S A NEW DRUG THAT SOUNDS PROMISING. LET'S HOPE THAT THE FDA GIVES IT THE emoticon

www.webmd.com/news/20051116/new-gout
-d
rug-twice-as-effective


SANDY emoticon

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