It's probably from your socks as opposed to shoes. If there is any sliding in the sock, that tiny bit of friction multiplied thousands of times will generate blisters.
Some recommend moisture wicking socks. You could also consider taping the affected area.
As far as treating blisters, I'm probably the worst person to ask. I will dip a needle in rubbing alcohol and pop those suckers because they drive me crazy. Someone with more sense would probably disagree with this approach.
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