A few suggestions.
Firstly, build up a solid base of walking
Secondly, keep your running pace down. Not much faster than a brisk walk, really.
Finally, the best way into running is a Couch to 5K program. Rather than running continuously, these programs work through progressively increasing intervals of running and walking. www.brainyweightloss.com/body-fat-percenta
Hopefully, by taking a very gradual approach to things, you will feel more confident that this program is comfortably within your limits, yet at the same time doing it regularly will extend those limits.
The reasonable man adapts himself to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore all progress depends on the unreasonable man.
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