It won't be impossible, but it will considerably difficult and complex to find out, say, 25 years or however long from now to see if different "control groups" can be compared in terms of those who just followed for many years healthy eating to those who followed a low-carb or Paleo or wheat free or Adkins diet. One, it will be difficult to find unbiased research; and, two, it will be difficult to find equal groups, whose weight loss, health, maintenance, etc are not connected to other factors besides their diets.
I shall go to my grave believing that the best "diet" is one of commonsense eating of healthy foods, generally avoiding too much processed meats like bacon and sausage, processed sugar foods, trans-fat and too much saturated fat, etc. I believe that consuming legumes, nuts and seeds, fruits, vegetables, lean meat and fish, whole wheat, etc. will be the best diet I can have.
"If any thing is sacred the human body is sacred...Have you seen the fool that corrupted his own live body? or the fool that corrupted her own live body? " -- Whitman
“Trust thyself: every heart vibrates to that iron string.” -- Emerson
"It's not what you look at that matters, it's what you see." -- Thoreau
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