I went to my family dr yesterday and he also started weaning me off of Wellbutrin and started Effexor. I am kinda nervous about starting it today, although I am having similar situation as the previous poster. I have been on Wellbutrin for God knows how long and it just not working anymore. My anxiety level is through the roof and there is no hope in sight with Wellbutrin. It's not that Wellbutrin is a bad product it's wonderful, but after umpteen years we are just not compatible. Dr stated some of the side effects that freaked me out but after some posts I am feeling a bit more at ease with it. I'll keep you up to date with my journey through the change. Lets just pray for results !