Thanks for another great comment on my blog. That is actually a very good question. And no, there is no harm in working two major muscle groups together. The only downside might be time, if they are both muscle groups you are particularly concerned about hitting. For instance, I doubt I would hit hams/glutes and chest in the same workout, because as hard as I go at it with each muscle group to try and bring it up, I'd just run out of enough energy to thoroughly work one or the other. I'd be more likely to put hams with back, or quads with chest.
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I hope you have a wonderful day and a terrific weekend. 1819 days ago