I've got about 120# to lose (well, 109 now, I guess!) so I thought I was probably okay for now...but if it's stretches out longer than the 4-6 weeks (or if I start feeling weak/sick), I'll increase my calories/cut back on working out.
I basically cut my calories in half - I'm staying at about 1400 after frequently eating 2500-3000 a day, and working out several times a week. I just have to make sure I stay motivated once the loss slows down! :)